YAC STS MAP OF 9 MB OF XQ26 AT 100-KB RESOLUTION, LOCALIZING 6 ESTS, 6 GENES, AND 32 GENETIC-MARKERS/

To facilitate functional analysis of the Xq26 region, the physical map has been extended across 9 Rib with 192 YACs and markers including 90 STSs (sequence-tagged sites) and 50 hybridization probes, Six genes a nd six ESTs are localized. In addition, 32 markers that detect polymor phism permit an integration of physical with genetic linkage data, The localizations of eight uncloned disease genes are thereby delimited o n the physical map, The data also suggest a possible gradient of recom bination across the cytogenetic band, with little or no recombination reported in the centromeric 3.5-4 Mb. (C) 1996 Academic Press, Inc.