5-HYDROXYANTHRANILIC ACID-DERIVATIVES AS POTENT 5-LIPOXYGENASE INHIBITORS

Three new 5-lipoxygenase inhibitors, designated as BU-4601 A, B and C, were found in the fermentation broth of Streptomyces sp. strain No. A A2807. Their structures were identified as isodecyl, isoundecyl and is olauryl esters of 5-hydroxyanthranilic acid, respectively. Based on th eir structures, five related esters were synthesized and evaluated for biological activity as inhibitors of 5-lipoxygenase. Both naturally-o ccurring and chemically-synthesized compounds exhibited almost equal l evels of 5-lipoxygenase inhibitory activities in vitro.