BENASTATIN-C AND BENASTATIN-D, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 - PRODUCTION, ISOLATION,STRUCTURE DETERMINATION AND BIOLOGICAL-ACTIVITIES

Authors
AOYAMA T KOJIMA F YAMAZAKI T TATEE T ABE F MURAOKA Y NAGANAWA H AOYAGI T TAKEUCHI T
Citation
T. Aoyama et al., BENASTATIN-C AND BENASTATIN-D, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 - PRODUCTION, ISOLATION,STRUCTURE DETERMINATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 46(5), 1993, pp. 712-718
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
5
Year of publication
1993
Pages
712 - 718
Database
ISI
SICI code
0021-8820(1993)46:5<712:BABNIO>2.0.ZU;2-Q
Abstract
Benastatin C, a new member of the benastatins, has been isolated from the culture broth of Streptomyces sp. MI384-DF12. The structure of ben astatin C was elucidated as 2-decarboxy-benastatin A by NMR studies. B enastatin D, 2-decarboxybenastatin B, was derived from benastatin B. B enastatins C and D showed inhibitory activities against human pi class glutathione S-transferase (GST pi) and excellent stimulatory activiti es on the murine lymphocyte blastogenesis in vitro.