LEPTOLSTATIN FROM STREPTOMYCES SP SAM1595, A NEW GAP PHASE-SPECIFIC INHIBITOR OF THE MAMMALIAN-CELL CYCLE .2. PHYSICOCHEMICAL PROPERTIES AND STRUCTURE

Authors
ABE K YOSHIDA M NAOKI H HORINOUCHI S BEPPU T
Citation
K. Abe et al., LEPTOLSTATIN FROM STREPTOMYCES SP SAM1595, A NEW GAP PHASE-SPECIFIC INHIBITOR OF THE MAMMALIAN-CELL CYCLE .2. PHYSICOCHEMICAL PROPERTIES AND STRUCTURE, Journal of antibiotics, 46(5), 1993, pp. 735-740
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
5
Year of publication
1993
Pages
735 - 740
Database
ISI
SICI code
0021-8820(1993)46:5<735:LFSSSA>2.0.ZU;2-T
Abstract
Leptolstatin, a product from Streptomyces sp. SAM1595, is a gap phase- specific inhibitor of the mammalian cell cycle. Physico-chemical prope rties and spectrometric analyses showed that the structure of leptolst atin is hyl-17-oxo-2,6,8,12,14,22-tetracosahexaen-5-olide.