XANTHOQUINODINS, NEW ANTICOCCIDIAL AGENTS PRODUCED BY HUMICOLA SP - PRODUCTION, ISOLATION AND PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

Humicola sp. FO-888, a soil isolate, was found to produce a series of new anticoccidial compounds. Five active compounds, designated xanthoq uinodins A1, A2, A3, B1 and B2 were isolated from the fermentation bro th of the producing strain by solvent extraction and HPLC. Xanthoquino dins inhibited the growth of Eimeria tenella in an in vitro assay syst em using BHK-21 cells as a host. No schizont in the cells was observed at concentrations of 0.02 - 0.2 mug/ml for xanthoquinodins A1, A3, B1 and B2 and at 0.02 mug/ml for xanthoquinodin A2.