SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SPERABILLIN DERIVATIVES

Modification of sperabillins was carried out. The 2-amidinoethylamino moiety was removed by brief acidic hydrolysis. The 2,4-hexadienoyl moi ety was hydrogenated to the hexanoyl moiety and this was cleaved by an enzymatic reaction using the cells of Pseudomonas acidovorans IFO 135 82. The 2-amidinoethylamino and the 2,4-hexadienoyl moieties were repl aced with other groups. The derivative which was prepared by condensat ion of two molar amounts of dehexadienoylsperabillin A with (E,E)-muco nic acid showed better protective effects than sperabillin A against G ram-negative bacteria.