SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE-CHAIN

Authors
OKITA T IMAE K HASEGAWA T IMURA S MASUYOSHI S KAMACHI H KAMEI H
Citation
T. Okita et al., SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE-CHAIN, Journal of antibiotics, 46(5), 1993, pp. 833-839
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
5
Year of publication
1993
Pages
833 - 839
Database
ISI
SICI code
0021-8820(1993)46:5<833:SAAAOC>2.0.ZU;2-Y
Abstract
CePhalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3 -(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and echol-4-ylcarb onyloxy)-1-propen-1-yl]cephalosporin (10) showed excellent activity ag ainst Gram-negative activity including ceftazidime-resistant Escherich ia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomon as cepacia.