THE MOLECULAR-BASIS OF SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES

Authors
STORB U
Citation
U. Storb, THE MOLECULAR-BASIS OF SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES, Current opinion in immunology, 8(2), 1996, pp. 206-214
Citations number
88
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
8
Issue
2
Year of publication
1996
Pages
206 - 214
Database
ISI
SICI code
0952-7915(1996)8:2<206:TMOSHO>2.0.ZU;2-6
Abstract
Somatic hypermutation amplifies the variable region repertoire of immu noglobulin genes. Recent experimental evidence has thrown light on var ious molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.