M. Csabayova et al., PSEUDORABIES VIRUS GROWTH-FACTOR (PRGF) FACILITATES THE GROWTH AND POSTNATAL-DEVELOPMENT OF MICE AND RATS, ACT VET B, 64(3-4), 1995, pp. 249-255
PRGFA, one of two components of pseudorabies virus (PRV) growth factor
(PRGF) facilitated the growth and postnatal development of newborn BA
LBc mice and outbred albino Wistar rats, when administered subcutaneou
sly. The growth proceeded much more rapidly and the initiation of hair
growth appeared considerably sooner in PRGFA treated than in control
animals. Susceptibility to PRGFA decreased with age, two days old anim
als proved to be the most susceptible and became non-susceptible at th
e age of 12 days. Two monoclonal antibodies (moabs) directed against g
II glycoprotein of PRV neutralized the growth stimulating activity of
PRGFA. Considering these findings, PRGFA is discussed as a potential n
ovel growth stimulator.