SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY ACTIVITY OF SOME N-(AROYL)-N-(ARYLALKYLOXY)-GLYCINES AND N-(AROYL)-N-(ARYLALKYLOXY)-BETA-ALANINES

Authors
MACCHIA M MENCHINI E NENCETTI S ORLANDINI E ROSSELLO A BELFIORE MS
Citation
M. Macchia et al., SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY ACTIVITY OF SOME N-(AROYL)-N-(ARYLALKYLOXY)-GLYCINES AND N-(AROYL)-N-(ARYLALKYLOXY)-BETA-ALANINES, Il Farmaco, 51(4), 1996, pp. 255-260
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
4
Year of publication
1996
Pages
255 - 260
Database
ISI
SICI code
0014-827X(1996)51:4<255:SAARIA>2.0.ZU;2-B
Abstract
Some N-(aroyl)-N-(phenylethyloxy)glycines (C) and N-(aroyl)-N-(arylmet hyloxy)beta-alanines (D) were synthesised and tested as aldose reducta se inhibitors (ARIs). Compounds C and D differ from the previously rep orted ARIs of type A in the presence of a further CH2 spacer between t he aryl moiety and the oxyamidic oxygen and between the oxyamidic nitr ogen and the carboxyl group. Compounds C revealed a certain loss of in hibitory activity with respect to the corresponding type A derivatives . Compounds D were found to be devoid of any appreciable inhibitory ac tivity.