SYNTHESIS AND IN-VITRO ANTITUMOR-ACTIVITY EVALUATION OF 9-SUBSTITUTED1,2,3,4-TETRAHYDROCARBAZOLES

Authors
GRASSO S MOLICA C MONFORTE AM MONFORTE P ZAPPALA M RIZZO M
Citation
S. Grasso et al., SYNTHESIS AND IN-VITRO ANTITUMOR-ACTIVITY EVALUATION OF 9-SUBSTITUTED1,2,3,4-TETRAHYDROCARBAZOLES, Il Farmaco, 51(4), 1996, pp. 269-274
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
4
Year of publication
1996
Pages
269 - 274
Database
ISI
SICI code
0014-827X(1996)51:4<269:SAIAEO>2.0.ZU;2-9
Abstract
A series of 9-acetamido-1,2,3,4-tetrahydrocarbazoles (2) and -(aminoal kyloxyethyl)-1,2,3,4-tetrahydrocarbazoles (4) were prepared and tested for their in vitro antitumor activity. Compounds 4 are highly cytotox ic in almost all subpanel cell lines when tested at 10(-4) M, but show ed a weak activity at the lowest concentrations employed.