2-DIAZOPYRROLES - SYNTHESIS AND ANTILEUKEMIC ACTIVITY

Authors
CIRRINCIONE G ALMERICO AM DIANA P GRIMAUDO S BARRAJA P DATTOLO G AIELLO E MINGOIA F
Citation
G. Cirrincione et al., 2-DIAZOPYRROLES - SYNTHESIS AND ANTILEUKEMIC ACTIVITY, Il Farmaco, 51(4), 1996, pp. 275-277
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
4
Year of publication
1996
Pages
275 - 277
Database
ISI
SICI code
0014-827X(1996)51:4<275:2-SAAA>2.0.ZU;2-V
Abstract
The title compounds were synthesised in preparative yields by diazotiz ation of the corresponding 2-aminopyrroles. In preliminary screening t ests as antileukemic agents they showed modest activity against the mu rine and human leukemic cell lines FLC and K562S and their multidrug-r esistant daunorubicin selected sublines.