SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF METHYLENEAMINOXY)-2-METHYLPROPIONAMIDO]SUBSTITUTED AND METHYLENEAMINOXY)-2-METHYLPROPIONAMIDO]SUBSTITUTED CEPHALOSPORANIC ACID-DERIVATIVES
M. Macchia et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF METHYLENEAMINOXY)-2-METHYLPROPIONAMIDO]SUBSTITUTED AND METHYLENEAMINOXY)-2-METHYLPROPIONAMIDO]SUBSTITUTED CEPHALOSPORANIC ACID-DERIVATIVES, Il Farmaco, 51(4), 1996, pp. 283-286
Some 7-amino cephalosporanic acid derivatives substituted on the C(7)
nitrogen with (S)- and (R)-3-(methyleneaminoxy)-2-methylpropionyl grou
ps were synthesised and tested in vitro for their antimicrobial activi
ty against Gram-positive and Gram-negative bacteria. Some of the new c
ompounds showed a modest activity directed only against Gram-positive
microorganisms.