SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF METHYLENEAMINOXY)-2-METHYLPROPIONAMIDO]SUBSTITUTED AND METHYLENEAMINOXY)-2-METHYLPROPIONAMIDO]SUBSTITUTED CEPHALOSPORANIC ACID-DERIVATIVES

Authors
MACCHIA M MENCHINI E ORLANDINI E ROSSELLO A BROCCALI G VISCONTI M
Citation
M. Macchia et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF METHYLENEAMINOXY)-2-METHYLPROPIONAMIDO]SUBSTITUTED AND METHYLENEAMINOXY)-2-METHYLPROPIONAMIDO]SUBSTITUTED CEPHALOSPORANIC ACID-DERIVATIVES, Il Farmaco, 51(4), 1996, pp. 283-286
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
4
Year of publication
1996
Pages
283 - 286
Database
ISI
SICI code
0014-827X(1996)51:4<283:SAAAOM>2.0.ZU;2-D
Abstract
Some 7-amino cephalosporanic acid derivatives substituted on the C(7) nitrogen with (S)- and (R)-3-(methyleneaminoxy)-2-methylpropionyl grou ps were synthesised and tested in vitro for their antimicrobial activi ty against Gram-positive and Gram-negative bacteria. Some of the new c ompounds showed a modest activity directed only against Gram-positive microorganisms.