TOTAL SYNTHESIS OF (-KIFUNENSINE, A POTENT GLYCOSIDASE INHIBITOR())

Authors
ROUDEN J HUDLICKY T
Citation
J. Rouden et T. Hudlicky, TOTAL SYNTHESIS OF (-KIFUNENSINE, A POTENT GLYCOSIDASE INHIBITOR()), Journal of the Chemical Society. Perkin transactions. I, (10), 1993, pp. 1095-1097
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
10
Year of publication
1993
Pages
1095 - 1097
Database
ISI
SICI code
0300-922X(1993):10<1095:TSO(AP>2.0.ZU;2-I
Abstract
(+)-Kifunensine, a potent inhibitor of mannosidase I, has been synthes ized in 13 steps from chlorobenzene by microbial oxygenation with Pseu domonas putida 39D and stereocontrolled peripheral functionalization o f cis-3-chlorocyclohexa-3,5-dienediol 3.