NEOSEPTA MICROPOROUS ION-EXCHANGE MEMBRANES IN DIALYSIS DESALINATION OF IMMUNOGLOBULIN FRACTION OF MOUSE ASCITIC FLUIDS

The transport properties of porous cation- and anion-exchange membrane s differing in pore size, porosity and ion-exchange capacity have been investigated in order to choose a membrane with an optimal set of pro perties suitable for the dialysis desalination of immunoglobulins (Igs ) (M(w) 180 000) of mouse ascitic fluids. The porosity of membranes is controlled by the conditions of synthesis. The membranes were employe d in the nontraditional dialysis process combining diffusion and conve ction. The duration of the process was considerably reduced (from 5 da ys to 2-6 h) and the Igs were better separated from accompanying low-m olecular-weight substances in comparison with conventional dialysis. T he influence of membrane properties and counterpressure imposed on the membrane to prevent the dialysate from an unnecessary dilution is dis cussed.