STUDIES ON THE SYNTHESIS OF CHOLECYSTOKIN IN-A RECEPTOR ANTAGONISTS .2. SYNTHESIS AND CHOLECYSTOKININ-A RECEPTOR INHIBITORY ACTIVITIES OF SULFUR-CONTAINING AMIDE-CARBOXYLIC ACID-DERIVATIVES

Authors
AJISAWA Y KITAZAWA M NAKANO Y TSUBAKI A BAN M SATO K OKAZAKI K KOBAYASHI M
Citation
Y. Ajisawa et al., STUDIES ON THE SYNTHESIS OF CHOLECYSTOKIN IN-A RECEPTOR ANTAGONISTS .2. SYNTHESIS AND CHOLECYSTOKININ-A RECEPTOR INHIBITORY ACTIVITIES OF SULFUR-CONTAINING AMIDE-CARBOXYLIC ACID-DERIVATIVES, Yakugaku zasshi, 116(5), 1996, pp. 396-410
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Yakugaku zasshi → ACNP
ISSN journal
00316903
Volume
116
Issue
5
Year of publication
1996
Pages
396 - 410
Database
ISI
SICI code
0031-6903(1996)116:5<396:SOTSOC>2.0.ZU;2-G
Abstract
A number of sulfur-containing amide-carboxylic acid derivatives were s ynthesized and tested for cholecystokinin A (CCR-A) receptor inhibitor y activity in order to study structure-activity relationships. Signifi cant CCK-A receptor inhibitory activities were found in only two serie s, that is, sulfoxide-carboxylic acid derivatives (9) and sulfone-carb oxylic acid derivatives (10). As the most preferred compound, yhenylsu ifonyl)-4-(N,N-dipentylcarbamoyl)pentanoic acid (10n) sas selected.