THE REGULATION MECHANISM OF C-JUN AND JUNB BY HUMAN PAPILLOMAVIRUS TYPE-16 E5 ONCOPROTEIN

Authors
CHEN SL HUANG CH TSAI TC LU KY TSAO YP
Citation
Sl. Chen et al., THE REGULATION MECHANISM OF C-JUN AND JUNB BY HUMAN PAPILLOMAVIRUS TYPE-16 E5 ONCOPROTEIN, Archives of virology, 141(5), 1996, pp. 791-800
Citations number
31
Categorie Soggetti
Virology
Journal title
Archives of virology → ACNP
ISSN journal
03048608
Volume
141
Issue
5
Year of publication
1996
Pages
791 - 800
Database
ISI
SICI code
0304-8608(1996)141:5<791:TRMOCA>2.0.ZU;2-Z
Abstract
In this study, we show that HPV-16 E5 induced anchorage-independent gr owth in immortalized human epidermal keratinocytes and that HPV-16 E5 in human keratinocytes had higher expression of c-jun and junB; also, we investigated the role of transcriptional initiation pathways in the expression elevation. In addition, Ras-dependent pathway, as well as PKC-dependent pathway, leads to HPV-16 E5-induced c-jun gene expressio n.