B. Winkelspecht et al., ANTI-EBNA1 ANTI-EBNA2 RATIO DECREASES SIGNIFICANTLY IN PATIENTS WITH PROGRESSION OF HIV-INFECTION/, Archives of virology, 141(5), 1996, pp. 857-864
Reactivation of EBV infection is common in immunocompromised individua
ls. We determined specific antibodies to EBV-encoded nuclear antigens
(EBNA) 1 and 2 in 102 sera of HIV-infected individuals. Anti-EBNA1/ant
iEBNA2 ratio (E1/E2) is less than 1 in chronic infection and exceeds 1
in healthy EBV-positive carriers. 52% of cases had E1/E2 < 1. E1/E2 d
ecreased remarkably during the progression of HIV infection. Detectabl
e HIV-Antigen, decline of CD4+ cell count and CD4+/CD8+ ratio were cor
related with an increasing prevalence of E1/E2 below 1. We conclude th
at determination of E1/E2 is useful in immunocompromised patients.