ENZYME-CATALYZED DESYMMETRIZATION OF MESO-SKIPPED POLYOLS TO USEFUL CHIRAL BUILDING-BLOCKS

Authors
BONINI C RACIOPPI R VIGGIANI L
Citation
C. Bonini et al., ENZYME-CATALYZED DESYMMETRIZATION OF MESO-SKIPPED POLYOLS TO USEFUL CHIRAL BUILDING-BLOCKS, Tetrahedron : asymmetry, 4(5), 1993, pp. 793-805
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
5
Year of publication
1993
Pages
793 - 805
Database
ISI
SICI code
0957-4166(1993)4:5<793:EDOMPT>2.0.ZU;2-W
Abstract
The biocatalytic desymmetrization, in presence of different enzymes, o f two models of polyfunctionalized diols in a meso form was studied PF L was found to be the most selective enzyme with excellent results in chemical and optical yield with some of the tested substrates. The obt ained chiral building block was utilized for some useful synthetic tra nsformations toward the synthesis of natural products.