CONVENIENT PRACTICAL RESOLUTION OF RACEMIC ALKYL-ARYL ALCOHOLS VIA ENZYMATIC ACYLATION WITH SUCCINIC ANHYDRIDE IN ORGANIC-SOLVENTS

Authors
GUTMAN AL BRENNER D BOLTANSKI A
Citation
Al. Gutman et al., CONVENIENT PRACTICAL RESOLUTION OF RACEMIC ALKYL-ARYL ALCOHOLS VIA ENZYMATIC ACYLATION WITH SUCCINIC ANHYDRIDE IN ORGANIC-SOLVENTS, Tetrahedron : asymmetry, 4(5), 1993, pp. 839-844
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
5
Year of publication
1993
Pages
839 - 844
Database
ISI
SICI code
0957-4166(1993)4:5<839:CPRORA>2.0.ZU;2-I
Abstract
Enantiomerically pure alkyl-aryl secondary alcohols were conveniently obtained on a kilogram scale from their racemic mixtures by enzymatic acylation with succinic anhydride in organic solvents. A major advanta ge of this acylation method is the ease of separating the ester from t he unreacted alcohol. This is achieved by extracting the organic solut ion with aqueous NaHCO3 after the enzymatic reaction is completed.