REGIOSELECTIVE AND ENANTIOSELECTIVE ESTERIFICATIONS OF POLYOXYGENATEDCOMPOUNDS CATALYZED BY LIPASES

Authors
HERRADON B CUETO S MORCUENDE A VALVERDE S
Citation
B. Herradon et al., REGIOSELECTIVE AND ENANTIOSELECTIVE ESTERIFICATIONS OF POLYOXYGENATEDCOMPOUNDS CATALYZED BY LIPASES, Tetrahedron : asymmetry, 4(5), 1993, pp. 845-864
Citations number
86
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
5
Year of publication
1993
Pages
845 - 864
Database
ISI
SICI code
0957-4166(1993)4:5<845:RAEEOP>2.0.ZU;2-D
Abstract
The lipase catalyzed esterifications of derivatives of propane-1,2,3-t riol and butane-1,2,4-triol in organic solvents have been studied. The influence of several factors (lipase source, organic solvent, additiv es and structural variations in die substrates) on the selectivity hav e been investigated. Good levels of regio- and enantioselectivity have been achieved, providing practical methods for the synthesis of these chiral building blocks.