SYNTHESIS OF AN AZT-HEPT HYBRID AND HOMOLOGOUS AZDDU DERIVATIVES

Authors
LARSEN E DANEL K VAABEN GB ELEMAM AA PEDERSEN EB NIELSEN C
Citation
E. Larsen et al., SYNTHESIS OF AN AZT-HEPT HYBRID AND HOMOLOGOUS AZDDU DERIVATIVES, Acta chemica Scandinavica, 50(5), 1996, pp. 417-421
Citations number
22
Categorie Soggetti
Chemistry,Biology
Journal title
Acta chemica Scandinavica → ACNP
ISSN journal
0904213X
Volume
50
Issue
5
Year of publication
1996
Pages
417 - 421
Database
ISI
SICI code
0904-213X(1996)50:5<417:SOAAHA>2.0.ZU;2-Y
Abstract
3'-Azido-2',3'-dideoxyuridines 6 and their corresponding cc anomers 5 were synthesized by condensation of silylated 6-alkyl and 5,6-dialkyl substituted uracils 2 with methyl l-2,3-dideoxy-alpha-beta-D-erythro-p entofuranoside (4). Compounds 5 and 6 were treated with tetrabutylammo nium fluoride to obtain the deprotected nucleosides 7 and 8, respectiv ely.