STEREOSELECTIVE HYDROLYSIS OF SUBSTITUTED CYCLOPENTANE DIESTERS WITH PIG-LIVER ESTERASE (PLE)

Authors
RENOLD P TAMM C
Citation
P. Renold et C. Tamm, STEREOSELECTIVE HYDROLYSIS OF SUBSTITUTED CYCLOPENTANE DIESTERS WITH PIG-LIVER ESTERASE (PLE), Tetrahedron : asymmetry, 4(5), 1993, pp. 1047-1050
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
5
Year of publication
1993
Pages
1047 - 1050
Database
ISI
SICI code
0957-4166(1993)4:5<1047:SHOSCD>2.0.ZU;2-8
Abstract
The hydrolysis of the dimethyl meso 1,2-cyclopentanedicarboxylates 1a, 2, 3, 4a, Sa, 6a and 7a, containing various substituents at C(4) with pig liver esterase (PLE) is described.The stereoselectivity and absol ute configurations of the resulting half esters were determined. In th e case of substrate 2 the bicyclic lactone 10 was isolated as product.