CARCINOGENIC RISK COEFFICIENTS AT ENVIRONMENTAL LEVELS OF RADON EXPOSURES - A MICRODOSIMETRIC APPROACH

We report a microdosimetric-based evaluation of the effects of domesti c exposure to radon. The risk coefficients obtained here are based on the microdosimetry of radon progeny alpha particles, on a function gel for in vivo radiogenic neoplasia, and on scaling A-bomb results (epid emiology + microdosimetry) to radon exposure. We do not use miner data , nor do we invoke such notions as quality factors, dose equivalent or equivalent dose. With basal cells as targets our estimated risk coeff icients are in good agreement with the miner data, and thus a quality factor of about 20 (as suggested by ICRP 60) is not unreasonable, Howe ver, if we take as targets the secretory cells our risk coefficients a re twice as large as those reported by BEIR-IV. The main uncertainty i n these estimates remains the dosimetric model.