DEVELOPMENT OF THE BIOCATALYTIC RESOLUTION OF 2-AZABICYCLO[2.2.1]HEPT-5-EN-3-ONE AS AN ENTRY TO SINGLE-ENANTIOMER CARBOCYCLIC NUCLEOSIDES

Authors
TAYLOR SJC MCCAGUE R WISDOM R LEE C DICKSON K RUECROFT G OBRIEN F LITTLECHILD J BEVAN J ROBERTS SM EVANS CT
Citation
Sjc. Taylor et al., DEVELOPMENT OF THE BIOCATALYTIC RESOLUTION OF 2-AZABICYCLO[2.2.1]HEPT-5-EN-3-ONE AS AN ENTRY TO SINGLE-ENANTIOMER CARBOCYCLIC NUCLEOSIDES, Tetrahedron : asymmetry, 4(6), 1993, pp. 1117-1128
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
6
Year of publication
1993
Pages
1117 - 1128
Database
ISI
SICI code
0957-4166(1993)4:6<1117:DOTBRO>2.0.ZU;2-5
Abstract
For the resolution of the bicyclic lactam 2-azabicyclo[2.2.1]hept-5-en -3-one, efficient whole cell biocatalysts have been identified and fro m these, enzymes (lactamases) have been isolated. While the two enzyme s obtained act on different enantiomers of the lactam, either can be u sed in scaleable processes to obtain synthons for carbocyclic nucleosi des having the natural configuration.