MICROBIAL HYDROXYLATION AND FUNCTIONALIZATION OF SYNTHETIC POLYCYCLICENONES

Authors
HAMMOUMI A GIRAULT JP AZERAD R REVIAL G DANGELO J
Citation
A. Hammoumi et al., MICROBIAL HYDROXYLATION AND FUNCTIONALIZATION OF SYNTHETIC POLYCYCLICENONES, Tetrahedron : asymmetry, 4(6), 1993, pp. 1295-1306
Citations number
41
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
6
Year of publication
1993
Pages
1295 - 1306
Database
ISI
SICI code
0957-4166(1993)4:6<1295:MHAFOS>2.0.ZU;2-T
Abstract
The regio- and stereoselective hydroxylation of variously substituted asymmetric 4a-methyl octalenones by selected fungal strains has been s hown to afford, sometimes in high yields, several optically pure deriv atives, generally hydroxylated in the B-ring. The potential of this me thod for the preparation of functionalized (hydroxylated) chiral synth ons is evaluated and discussed.