Neuroleptic malignant syndrome is a rare, idiosyncratic condition rela
ted to neuroleptic use which may develop at any stage during neurolept
ic treatment and can prove fatal Although most commonly seen in psychi
atric patients, anyone prescribed a neuroleptic is at risk and it has
been associated with other agents. This article discusses its recognit
ion, risk factors, clinical course and treatment, together with a summ
ary of current thinking on its aetiology.