EFFECT OF PULSE ON IONTOPHORETIC DELIVERY OF DESMOPRESSIN ACETATE IN RATS

The effect of pulse parameters (duty and frequency) in a constant dire ct current iontophoresis on the antidiuretic response (elevation in ra t urinary osmotic pressure) of desmopressin acetate (DDAVP) was examin ed in diabetes insipidus rats. Although antidiuretic response was not affected by frequency, it,vas induced by a duty of more than 26% and p rolonged with increasing duty, A positively relationship between dose and AUC, the area under the osmotic pressure-time curve, was confirmed by intravenous administration of DDAVP, and the AUC induced by the io ntophoretic delivery increased with increasing duty, The voltage acros s rat skin required to maintain a constant current density was investi gated. A higher voltage was initially applied rat skin in a higher dut y, This was related the prolonged pharmacological response induced by iontophoresis.