M. Nakakura et al., EFFECT OF PULSE ON IONTOPHORETIC DELIVERY OF DESMOPRESSIN ACETATE IN RATS, Biological & pharmaceutical bulletin, 19(5), 1996, pp. 738-740
The effect of pulse parameters (duty and frequency) in a constant dire
ct current iontophoresis on the antidiuretic response (elevation in ra
t urinary osmotic pressure) of desmopressin acetate (DDAVP) was examin
ed in diabetes insipidus rats. Although antidiuretic response was not
affected by frequency, it,vas induced by a duty of more than 26% and p
rolonged with increasing duty, A positively relationship between dose
and AUC, the area under the osmotic pressure-time curve, was confirmed
by intravenous administration of DDAVP, and the AUC induced by the io
ntophoretic delivery increased with increasing duty, The voltage acros
s rat skin required to maintain a constant current density was investi
gated. A higher voltage was initially applied rat skin in a higher dut
y, This was related the prolonged pharmacological response induced by
iontophoresis.