Mr. Karagas et al., PATTERNS OF FRACTURE AMONG THE UNITED-STATES ELDERLY - GEOGRAPHIC ANDFLUORIDE EFFECTS, Annals of epidemiology, 6(3), 1996, pp. 209-216
The purpose of this study was to examine whether geographic area or wa
ter fluoride were related to the occurrence of fractures among the eld
erly in the United States. We used a 5% sample of the white U.S. Medic
are population, aged 65 to 89 years during the period 1986-1990, to id
entify fractures of the hip, proximal humerus, distal forearm, and ank
le. The association of geographic region and fluoridation status with
fracture rates was assessed using Poisson regression. We found that ra
tes of hip fracture were generally lower in the northern regions of th
e United States and higher in the southern regions. For fractures of t
he distal forearm and proximal humerus, lower rates were found in the
Western states, and higher rates in the East. No discernible geographi
c pattern was found for ankle fractures. Adjustment for water fluorida
tion did not influence these results. Independent of geographic effect
s, men in fluoridated areas had modestly higher rates of fractures of
the distal forearm and proximal humerus than did men in nonfluoridated
areas; no such differences were observed among women, nor for fractur
es of the hip or ankle among either men or women. In conclusion, our d
ata suggest that fractures of the distal forearm and proximal humerus
have etiologic determinants distinct from those of fractures of the hi
p or ankle.