Jwr. Twisk et al., RELATION BETWEEN THE LONGITUDINAL DEVELOPMENT OF LIPOPROTEIN LEVELS AND LIFE-STYLE PARAMETERS DURING ADOLESCENCE AND YOUNG ADULTHOOD, Annals of epidemiology, 6(3), 1996, pp. 246-256
The longitudinal relationship between serum levels of lipoproteins and
lifestyle measures (e.g., intake of cholesterol, carbohydrates, satur
ated fatty acids [SFA], polyunsaturated fatty acids [PUFA], the PUFA/S
FA (P:S) ratio, alcohol consumption, smoking behavior, and daily physi
cal activity) was investigated over a period of 15 years in a cohort s
tudy (the Amsterdam Growth and Health Study). Members of the cohort we
re 13 years of age at commencement of the study and were 27 years old
at termination. The unique feature of the study presented is that the
longitudinal relations were analyzed with generalized estimating equat
ions, a statistical technique in which the relations at different time
-points are tested simultaneously. The development of the total serum
cholesterol (TC) level was positively related to the intake of cholest
erol and negatively to the P:S ratio. The development of high-density-
lipoprotein cholesterol (HDL) level was positively related to alcohol
consumption and daily physical activity and negatively to smoking beha
vior. The development of the TC:HDL ratio was negatively related to al
cohol consumption and positively to both smoking behavior and carbohyd
rate intake.