A GENERAL AND CONVENIENT SYNTHESIS OF NOVEL PHOSPHOTYROSINE MIMETICS

Authors
SZARDENINGS AK GORDEEV MF PATEL DV
Citation
Ak. Szardenings et al., A GENERAL AND CONVENIENT SYNTHESIS OF NOVEL PHOSPHOTYROSINE MIMETICS, Tetrahedron letters, 37(21), 1996, pp. 3635-3638
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
21
Year of publication
1996
Pages
3635 - 3638
Database
ISI
SICI code
0040-4039(1996)37:21<3635:AGACSO>2.0.ZU;2-G
Abstract
A simple and general procedure for preparation of various phosphotyros ine mimetics from the corresponding phenolic precursors is described. In situ silylation of phenol acids followed by treatment with Et(3)N/C Br4/HP(O)(OEt)(2) provides diethyl phosphate intermediates (36-96%), w hich can be cleanly deprotected in quantitative yields upon treatment with BSTFA/TMSI to afford novel phosphotyrosine mimetics. Copyright (C ) 1996 Elsevier Science Ltd.