1-[2-(TRIMETHYLSILYL)ETHOXY]ETHYL (SEE) - A NOVEL HYBRID HYDROXY-PROTECTING GROUP BETWEEN 1-(ETHOXY)ETHYL (EE) AND 2-(TRIMETHYLSILYL)ETHOXYMETHYL (SEM)

Authors
WU JJ SHULL BK KOREEDA M
Citation
Jj. Wu et al., 1-[2-(TRIMETHYLSILYL)ETHOXY]ETHYL (SEE) - A NOVEL HYBRID HYDROXY-PROTECTING GROUP BETWEEN 1-(ETHOXY)ETHYL (EE) AND 2-(TRIMETHYLSILYL)ETHOXYMETHYL (SEM), Tetrahedron letters, 37(21), 1996, pp. 3647-3650
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
21
Year of publication
1996
Pages
3647 - 3650
Database
ISI
SICI code
0040-4039(1996)37:21<3647:1(-ANH>2.0.ZU;2-3
Abstract
The highly versatile 1-[(2-trimethylsilyl)ethoxy]ethyl (SEE) group, re adily obtainable from an alcohol and 2-(trimethylsilyl)ethyl vinyl eth er in the presence of a catalytic amount of PPTS, has been developed f or the protection of hydroxyl groups. Its deprotection can be achieved under virtually neutral conditions with the use of a fluoride ion sou rce, thus allowing for effective protection of hydroxyl groups of comp ounds that contain acid- and/or base-sensitive functional groups. Copy right (C) 1996 Elsevier Science Ltd.