PROTECTION, METALATION, AND ELECTROPHILIC SUBSTITUTION OF 5-METHYL TETRAZOLE

Authors
HUFF BE LETOURNEAU ME STASZAK MA WARD JA
Citation
Be. Huff et al., PROTECTION, METALATION, AND ELECTROPHILIC SUBSTITUTION OF 5-METHYL TETRAZOLE, Tetrahedron letters, 37(21), 1996, pp. 3655-3658
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
21
Year of publication
1996
Pages
3655 - 3658
Database
ISI
SICI code
0040-4039(1996)37:21<3655:PMAESO>2.0.ZU;2-8
Abstract
5-Methyl tetrazole was N-protected with the trityl group and deprotona ted using n-BuLi. The resulting 5-methyl anion was trapped with a vari ety of electrophiles to provide B-substituted tetrazoles in good yield s. The trityl protecting group was readily removed using HCl in methyl ene chloride. Copyright (C) 1996 Elsevier Science Ltd.