ANTICLASTOGENIC EFFECTS OF GALANGIN AGAINST MITOMYCIN C-INDUCED MICRONUCLEI IN RETICULOCYTES OF MICE

We investigated the suppressive effect of galangin on the induction of micronucleated reticulocytes (MNRETs) by mitomycin C (MMC) in mouse p eripheral blood. When galangin was given to mice 24 h before the intra peritoneal injection of MMC (1 mg/kg), a more marked decrease in the f requency of MNRETs was observed than in mice with simultaneous and pos t-treatment of galangin. On the other hand, when galangin was given to mice for 7 consecutive days before MMC injection, galangin showed pot ent anticlastogenic effects, even at the lowest dose level of 0.1 mg/k g. Results from our in vivo studies indicate that galangin is capable of suppressing the clastogenic activity of the direct acting MMC. Toge ther with our earlier observations, it appears that galangin is capabl e of protecting cells from the toxic effects of a variety of hazardous chemicals. Therefore, galangin may be an useful chemopreventive compo und.