DRUG-CYTOKINE INTERACTIONS - FOCUS ON CYCLOSPORINE

The immune system is a complex network that regulates and maintains th e host's defense system. Changes and alterations in the immune system precipitate a series of reactions to prevent further damage as well as initiate repair. The system's cellular component relies on cytokines (interleukins, tumor necrosis factor, interferons, etc.) to facilitate communication in response to a foreign antigen. Cytokine concentratio ns are therefore elevated during times of inflammation, such as reject ion of a transplanted organ. Recent research suggests that interleukin -6 may have an inhibitory effect on cytochrome P-450 3A and thus affec t drug metabolism. Cyclosporine, which is administered to prevent reje ction of transplanted organs, is metabolized primarily by the P-450 3A system. Thus, the inhibitory effect of interleukin-6 may alter cyclos porine concentrations, which in turn may increase its adverse effects, such as nephrotoxicity.