CLEARANCE OF TICARCILLIN-CLAVULANIC ACID BY CONTINUOUS VENOVENOUS HEMOFILTRATION IN 3 CRITICALLY ILL CHILDREN, 2 WITH AND ONE WITHOUT CONCOMITANT EXTRACORPOREAL MEMBRANE-OXYGENATION

Three children were receiving ticarcillin-clavulanic acid by continuou s venovenous hemofiltration (CVVH). Two of them were also receiving co ncomitant extracorporeal membrane oxygenation (ECMO). We collected ult rafiltrate hourly to determine the clearance of ticarcillin-clavulanic acid by CVVH. Serum concentrations were also determined at the midpoi nt of each ultrafiltrate collection, All samples were collected over o ne dosing interval. The volume of distribution of ticarcillin and clav ulanic acid was 0.26. +/- 0.01 and 0.69 +/- 0.23 L/kg, respectively. T otal body clearance of ticarcillin, determined from the elimination ra te constant and volume of distribution, was 0.038 +/- 0.003 L/kg/hour and for clavulanic acid was 0.18 +/- 0.03 L/kg/hour. The sieving coeff icients for ticarcillin and clavulanic acid were 0.83 +/- 0.11 and 1.6 9 +/- 0.19, respectively. We attempted to estimate the clearances by E CMO, but the result was uninterpretable.