A 64-year-old man with narcolepsy could not take stimulant drugs due t
o coronary heart disease. In the past he noted improvement in alertnes
s when taking codeine for pain, but this was eventually discontinued.
After he developed end-stage renal disease, and because the use of sti
mulants in this setting may be difficult, treatment with codeine was a
gain initiated. This resulted in dramatic improvement in alertness and
substantial reduction of cataplexy. Because it is simple to use and f
amiliar to most physicians, codeine may be the drug of choice for narc
oleptic patients who are undergoing hemodialysis.