THE INFLUENCE OF PLOIDY ON THE DISTRIBUTION OF CELLS IN CHIMERIC MOUSE BLASTOCYSTS

Citation
Ca. Everett et Jd. West, THE INFLUENCE OF PLOIDY ON THE DISTRIBUTION OF CELLS IN CHIMERIC MOUSE BLASTOCYSTS, Zygote, 4(1), 1996, pp. 59
Citations number
26
Categorie Soggetti
Developmental Biology","Cell Biology
Journal title
ZygoteACNP
ISSN journal
09671994
Volume
4
Issue
1
Year of publication
1996
Database
ISI
SICI code
0967-1994(1996)4:1<59:TIOPOT>2.0.ZU;2-L
Abstract
Previous studies of tetraploid <----> diploid mouse chimaeras and mosa ics have revealed that tetraploid cells do not contribute equally to a ll tissues of the conceptus. In this study we have shown that, within 30 h of aggregating cleavage stage embryos, tetraploid cells were non- randomly distributed among different tissues of the early blastocyst. They were preferentially allocated to the mural trophectoderm regardle ss of cell size at the time of aggregation. This early effect-may unde rlie the restricted distribution of tetraploid cells at later stages. We have demonstrated for the first time that ploidy can influence the relative position of blastomeres in the preimplantation embryo.