GENETIC EPIDEMIOLOGIC-STUDY OF POLYDACTYL Y IN CHILE

Authors
CIFUENTES L NAZER J HUBER ME RAMIREZ R NAZER C MORALES I
Citation
L. Cifuentes et al., GENETIC EPIDEMIOLOGIC-STUDY OF POLYDACTYL Y IN CHILE, Revista Medica de Chile, 124(3), 1996, pp. 313-318
Citations number
15
Categorie Soggetti
Medicine, General & Internal
Journal title
Revista Medica de Chile → ACNP
ISSN journal
00349887
Volume
124
Issue
3
Year of publication
1996
Pages
313 - 318
Database
ISI
SICI code
0034-9887(1996)124:3<313:GEOPYI>2.0.ZU;2-C
Abstract
The aim of this work was to study the prevalence at birth and family a ggregation of polydactyly in Chile. We studied 125.652 newborns betwee n 1969 and 1991. The prevalence was 1.329 for each 1.000 live newborns and higher in males than in females. Familial recurrence was 22.5% an d gene penetrance was estimated as 0.5 for the postaxial-A type and 0. 3 for the postaxial-B type. Gene penetrance for postaxial-B type was h igher in males. Estimation of gene frequencies and mutation rates gave the highest values for postaxial-B polydactyly.