Ay. Rostom et al., ONCE WEEKLY IRRADIATION FOR CARCINOMA OF THE BLADDER, International journal of radiation oncology, biology, physics, 35(2), 1996, pp. 289-292
Citations number
12
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Purpose: A dose-searching study was carried out treating selected elde
rly patients or patients with poor performance with bladder cancer wit
h once weekly fractionation to determine an effective dose per fractio
n, and to evaluate acute and late effects resulting from this schedule
. Methods and Materials: Seventy patients with invasive transitional c
ell carcinoma of the bladder were entered in the study, The dose used
was 36-39 Gy in six fractions over 35 days in 27 patients (Group 1), T
he remaining 43 patients were treated with 34.5 Gy in six fractions ov
er 39 days (Group 2). Results: Six patients developed Grade 1-2 Europe
an Organization for Research on Treatment of Cancer (EORTC) bowel reac
tion, Three patients in Group 1 developed Grade 3 late bowel reaction
and a fourth patient developed Grade 4 reaction requiring colostomy, H
owever, only one patient in Group 2 developed Grade 3 reaction. The di
fference between the two groups was statistically significant (chi(2)
= 3.794, P = 0.05). Conclusions: The acute and late reaction as well a
s the 5-year free survival for patients in Group 2 compare favorably w
ith daily treatment, We conclude that 34.5 Gy given over 39 days is a
safe and effective treatment for selected patients with bladder cancer
.