ONCE WEEKLY IRRADIATION FOR CARCINOMA OF THE BLADDER

Citation
Ay. Rostom et al., ONCE WEEKLY IRRADIATION FOR CARCINOMA OF THE BLADDER, International journal of radiation oncology, biology, physics, 35(2), 1996, pp. 289-292
Citations number
12
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
03603016
Volume
35
Issue
2
Year of publication
1996
Pages
289 - 292
Database
ISI
SICI code
0360-3016(1996)35:2<289:OWIFCO>2.0.ZU;2-T
Abstract
Purpose: A dose-searching study was carried out treating selected elde rly patients or patients with poor performance with bladder cancer wit h once weekly fractionation to determine an effective dose per fractio n, and to evaluate acute and late effects resulting from this schedule . Methods and Materials: Seventy patients with invasive transitional c ell carcinoma of the bladder were entered in the study, The dose used was 36-39 Gy in six fractions over 35 days in 27 patients (Group 1), T he remaining 43 patients were treated with 34.5 Gy in six fractions ov er 39 days (Group 2). Results: Six patients developed Grade 1-2 Europe an Organization for Research on Treatment of Cancer (EORTC) bowel reac tion, Three patients in Group 1 developed Grade 3 late bowel reaction and a fourth patient developed Grade 4 reaction requiring colostomy, H owever, only one patient in Group 2 developed Grade 3 reaction. The di fference between the two groups was statistically significant (chi(2) = 3.794, P = 0.05). Conclusions: The acute and late reaction as well a s the 5-year free survival for patients in Group 2 compare favorably w ith daily treatment, We conclude that 34.5 Gy given over 39 days is a safe and effective treatment for selected patients with bladder cancer .