DETERMINATION OF ASPOXICILLIN IN BRONCHOALVEOLAR LAVAGE FLUID BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH PHOTOLYSIS AND ELECTROCHEMICALDETECTION

Authors
YAMAZAKI T ISHIKAWA T NAKAI H MIYAI M TSUBOTA T ASANO K
Citation
T. Yamazaki et al., DETERMINATION OF ASPOXICILLIN IN BRONCHOALVEOLAR LAVAGE FLUID BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH PHOTOLYSIS AND ELECTROCHEMICALDETECTION, Journal of chromatography. Biomedical applications, 615(1), 1993, pp. 180-185
Citations number
11
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography. Biomedical applications → ACNP
ISSN journal
03784347
Volume
615
Issue
1
Year of publication
1993
Pages
180 - 185
Database
ISI
SICI code
0378-4347(1993)615:1<180:DOAIBL>2.0.ZU;2-P
Abstract
A determination method for the penicillin antibiotic aspoxicillin in b roncho-alveolar lavage fluid has been developed, involving high-perfor mance liquid chromatography and post-column photolysis. The method ena bled the determination of aspoxicillin at concentrations below 100 ng/ ml, with a linear calibration curve at concentrations of 1-1000 ng/ml for 100 mul of lavage fluid. The detection limit was 1 ng/ml at a sign al-to-noise ratio of 3:1.