POLYAMINE-INDUCED COMPACTION AND AGGREGATION OF DNA - A MAJOR FACTOR IN RADIOPROTECTION OF CHROMATIN UNDER PHYSIOLOGICAL CONDITIONS

Authors
NEWTON GL AGUILERA JA WARD JF FAHEY RC
Citation
Gl. Newton et al., POLYAMINE-INDUCED COMPACTION AND AGGREGATION OF DNA - A MAJOR FACTOR IN RADIOPROTECTION OF CHROMATIN UNDER PHYSIOLOGICAL CONDITIONS, Radiation research, 145(6), 1996, pp. 776-780
Citations number
43
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Radiation research → ACNP
ISSN journal
00337587
Volume
145
Issue
6
Year of publication
1996
Pages
776 - 780
Database
ISI
SICI code
0033-7587(1996)145:6<776:PCAAOD>2.0.ZU;2-X
Abstract
Spermine at physiological levels and ionic strength induces compaction and aggregation of SV40 DNA and minichromosomes resulting in marked r adioprotection of the DNA against gamma-ray-induced formation of singl e-strand breaks. This phenomenon, termed the PICA effect, results in y ields of single-strand breaks in DNA and minichromosomes comparable to those found with intact cells and is considered to be a major mechani sm responsible for radioprotection of cellular DNA. (C) 1996 by Radiat ion Research Society