CARBOHYDRATE BUILDING-BLOCKS IN HETEROCYCLIC CHEMISTRY - SYNTHETIC STUDIES DIRECTED TOWARDS THE HERBICIDINS

Authors
BINCH HM GRIFFIN AM GALLAGHER T
Citation
Hm. Binch et al., CARBOHYDRATE BUILDING-BLOCKS IN HETEROCYCLIC CHEMISTRY - SYNTHETIC STUDIES DIRECTED TOWARDS THE HERBICIDINS, Pure and applied chemistry, 68(3), 1996, pp. 589-592
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Pure and applied chemistry → ACNP
ISSN journal
00334545
Volume
68
Issue
3
Year of publication
1996
Pages
589 - 592
Database
ISI
SICI code
0033-4545(1996)68:3<589:CBIHC->2.0.ZU;2-X
Abstract
Recent synthetic studies directed towards the herbicidin class of nucl eosides are described Aldehyde 7, incorporating the requisite adenine unit, has been prepared but failed to undergo base-induced aldol react ions with ketone 3. This problem was overcome using the cerium enolate corresponding to 3, which is generated from alpha-bromoketone 9. Reac tion of this species with aldehyde 7 leads to the enone 8.