ALPHA-CARBONYL RADICALS FOR TOTAL SYNTHESIS OF NATURAL-PRODUCTS

Authors
SHA CK JEAN TS YAU NT HUANG SJ CHIOU RT YOUNG JF LIH SH TSENG WH
Citation
Ck. Sha et al., ALPHA-CARBONYL RADICALS FOR TOTAL SYNTHESIS OF NATURAL-PRODUCTS, Pure and applied chemistry, 68(3), 1996, pp. 687-689
Citations number
6
Categorie Soggetti
Chemistry
Journal title
Pure and applied chemistry → ACNP
ISSN journal
00334545
Volume
68
Issue
3
Year of publication
1996
Pages
687 - 689
Database
ISI
SICI code
0033-4545(1996)68:3<687:ARFTSO>2.0.ZU;2-C
Abstract
alpha-Carbonyl radicals, generated from the corresponding alpha-iodo k etones, enones, or vinylogous esters and amides, undergo intramolecula r cyclization to the tethered trimethylsilylacetylenic side chain to a fford the bicyclic vinylsilane ketone or enones. These radical cycliza tions are applied to total syntheses of natural products.