TOWARDS THE ASYMMETRIC SYNTHESIS OF BRYOSTATIN-1

Authors
DEBRABANDER J VANDEWALLE M
Citation
J. Debrabander et M. Vandewalle, TOWARDS THE ASYMMETRIC SYNTHESIS OF BRYOSTATIN-1, Pure and applied chemistry, 68(3), 1996, pp. 715-718
Citations number
26
Categorie Soggetti
Chemistry
Journal title
Pure and applied chemistry → ACNP
ISSN journal
00334545
Volume
68
Issue
3
Year of publication
1996
Pages
715 - 718
Database
ISI
SICI code
0033-4545(1996)68:3<715:TTASOB>2.0.ZU;2-N
Abstract
The construction of the fragments C-1-C-9 3 and C-17-C-27 4a of the br yostatins in a enantioselective and highly diastereoselective fashion is described, The usefulness of the ''chiron'' approach is illustrated with the synthesis of these fragments from respectively D-pantolacton e (6) and D-isobutyl lactate (14) as chiral templates.