MASS-SPECTRAL STUDY OF ETOPOSIDE

The antitumour agent etoposide has been studied under electron impact, chemical ionization and liquid secondary ion mass spectral conditions , The major fragment ions are found to be due to the cleavage of C-4-O , C4O-glycoside and C-1-C'(1) bonds, These fragmentation pathways are established by collision-induced dissociation and accurate mass measur ement, Mass spectral studies of 4'-demethylepipodophyllotoxin, epipodo phyllotoxin and their respective-p-fluoroanilidine derivatives were al so carried out.