CYST SCLEROTHERAPY WITH MINOCYCLINE HYDROCHLORIDE IN PATIENTS WITH AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY-DISEASE

Background. The enlarged cysts in autosomal dominant polycystic kidney disease (ADPKD) frequently cause abdominal discomfort. Cyst sclerothe rapy with minocycline hydrochloride was performed to relieve this symp tom. Methods. Ten symptomatic ADPKD cases were recruited. As a scleros ant, minocycline hydrochloride solution (10 mg/dl) was used. This solu tion was instilled into the cysts under ultrasonographic control. Rena l volume was calculated before therapy and at 6-month intervals therea fter. Renal function and blood pressure were regularly monitored. The effect of sclerotherapy on symptoms was also assessed at 6-month inter vals. Results. At 6 months, renal volume was statistically lower than the presclerotherapy, and was associated with improvement in chronic s ymptoms. However, such ameliorating effects were blunted at 12 months, Renal volume reduction at 6 and 12 months showed a significant positi ve correlation with the dose of minocycline injected. No significant i nfluence in renal function and blood pressure was observed. Conclusion s. These results suggest that cyst sclerotherapy with minocycline hydr ochloride is a valid treatment regime for the relief of chronic sympto ms in ADPKD cases, although repeated application of this approach may be required to obtain a more long-term effect.