T. Sato et al., POTENTIATION OF L-DOPA-INDUCED BEHAVIORAL EXCITEMENT BY HISTAMINE H-1-RECEPTOR ANTAGONISTS IN MICE, Japanese Journal of Pharmacology, 71(1), 1996, pp. 81-84
Effects of histamine H-1-receptor antagonists on L-dopa-induced behavi
oral excitement were examined in mice to confirm behaviorally the inhi
bition of dopamine uptake by these compounds. L-Dopa (100-300 mg/kg, s
.c.) combined with pargyline hydrochloride (80 mg/kg, i.p.) caused a d
ose-dependent behavioral excitement. The marked excitement induced by
L-dopa (300 mg/kg) plus pargyline was significantly inhibited by pimoz
ide (0.1-1 mg/kg, s.c.), a selective dopamine antagonist. Tripelennami
ne (10 mg/kg, s.c.), d-chlorpheniramine (1 and 2 mg/kg, s.c.), homochl
orcyclizine (2 and 5 mg/kg, s.c.), diphenhydramine (2 and 5 mg/kg, s.c
.) and mepyramine (2 and 5 mg/kg, s.c.) each markedly enhanced the mod
erate behavioral excitement induced by L-dopa (150 mg/kg) plus pargyli
ne. These findings are behavioral evidence for inhibition of dopamine
uptake by H-1 antagonists, which has been suggested by neurochemical s
tudies.