INFLUENCE OF DIABETES-MELLITUS AND GLYCEMIC CONTROL ON THE CHARACTERISTICS AND OUTCOME OF COMMON INFECTIONS

The aim of the present study was to elucidate the effect of diabetes a nd metabolic control on the presentation, sources, pathogens and outco me of common infections. Of 515 patients admitted to three departments of internal medicine because of a suspected acute infection, 132 (26 %) had diabetes mellitus. Osteomyelitis was diagnosed in 3 % of the di abetic patients and in 1 % of patients without diabetes, and infection of the extremities in 7 % and 0 %, respectively (p = 0.003). Klebsiel la sp. caused 24 % of urinary tract infections in diabetic patients, v ersus 13 % in patients without diabetes (p = 0.1). The percentage of S taphylococcus aureus infections in diabetic patients was 10 % versus 5 % in non-diabetic patients (p = 0.06). The gross mortality rate in th e diabetic patients was 10 %, and in patients without diabetes, 12 %. In patients without fatal underlying disorders, mortality in the diabe tic patients was 10 % (2 % in patients with glycosylated haemoglobin ( GHb) lower than median, and 17 % in patients with GHb higher than medi an) and in the non-diabetic patients 4 % (p = 0.04). Five factors were independently and significantly related to mortality in diabetic pati ents: acute respiratory distress (very large odds-ratio [OR]), coma (O R 3.8, 95 % confidence interval [CI] 1.0-14.3), GHb above the median ( OR 3.3, 95 % CI 1.8-6.2), the interaction between GHb and absence of a severe underlying disorder (OR 12.0, 95 % CI 2.9-50.7) and duration o f diabetes (OR of 1.072 for 1-year increment, and 1.42 for a 5-year in crement). Choice of empiric antibiotic treatment in diabetic patients with suspected bacterial infection should take into account the prepon derance of Klebsiella sp. and Staphylococcus aureus infections. The pr esent results favour an association between poor glycaemic control and a fatal outcome of infectious diseases in diabetic patients.