DIFFERENCES IN THE NEUROPEPTIDE Y-LIKE IMMUNOREACTIVITY OF THE PLASMAAND PLATELETS OF HUMAN VOLUNTEERS AND DEPRESSED-PATIENTS

Authors
NILSSON C KARLSSON G BLENNOW K HEILIG M EKMAN R
Citation
C. Nilsson et al., DIFFERENCES IN THE NEUROPEPTIDE Y-LIKE IMMUNOREACTIVITY OF THE PLASMAAND PLATELETS OF HUMAN VOLUNTEERS AND DEPRESSED-PATIENTS, Peptides, 17(3), 1996, pp. 359-362
Citations number
27
Categorie Soggetti
Biology
Journal title
Peptides → ACNP
ISSN journal
01969781
Volume
17
Issue
3
Year of publication
1996
Pages
359 - 362
Database
ISI
SICI code
0196-9781(1996)17:3<359:DITNYI>2.0.ZU;2-Z
Abstract
In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet-poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differe nces in the NPY-LI in platelet-poor plasma (PPP) and platelets were de tected when the samples were analyzed by HPLC followed by RIA of the c ollected fractions.